Abstract:

Retinal neovascularization is a complex and interactive result among various vascular factors. Angiogenesis inhibitors, such as pigment epithelium derived factor, angiostatin, endostatin, tissue inhibitor of metalloproteinase, thrombospondin-1, soluble fms-like tyrosine kinase-1, plasminogen activator inhibitor-1, arrestin, α-melanocyte-stimulating homone, can inhibit angiogenesis. Its mechanisms of action include inhibiting the division and migration of endothelial cells, reducing the activity of endothelial cells, promoting the death of endothelial cells, interfering with the interaction between basement membrane and endothelial cells, inhibiting the proteolytic reaction and the adhesion movement of endothelial cells and down regulating expression of several pro\|angiogenic factors. The angiogenesis have potential clinical significance for prevention and treatment of retinal neovascularization. (Int Rev Ophthalmol, 2019, 43: 385-389)